It seems like there's not a hierarchy of sins in V5, but a mixture of touchstones (as they are in Requiem?) and collaboratively decided upon tenants.
That in mind, I'd probably introduce a houserule that fully satiating your hunger will always taint (giggle) your humanity. It's not about hunger at that point, as you may drink and drink and never get rid of that last die. That complete satisfaction comes from the kill, and I'd rule that that is the beast getting what it wants, not the human. (Their wants may coincide in a particularly twisted and sadistic human, but it's still a win for the beast.) The human may offer up justifications for why murdering was the "right" thing to do at that point, but that's our psyches trying to protect itself.
The "be a human, not a monster" tenant does creating an interesting distinction between human evil and bestial evil (if it even is evil at that point). It highlights a potential trope of Vampire I particularly enjoy: these vast schemes, the treachery, the conspiracies and callous atrocities; that's all the human part of the vampire. The beast is only worried with more immediate concerns, ie. "the four Fs": fighting, fleeing, feeding and procreating.
What's the greater evil? To maintain your humanity, or to allow yourself to become a blissfully ignorant (perhaps even innocent) beast? 😄