There was an interesting vampire book I read where the lord of the vampires was trying to blot out the moon, because the sunlight reflected by it caused him to pass out in pain. Only during the new moon was he truly pain-free. So at the end of the book, he performed a great ritual that shattered the moon into an asteroid cloud that surrounded the Earth, blocking out all light and allowing him to turn loose hordes of Vampires that killed everything. The story ended (as I recall it) with him hunting down the vampires, and draining them one by one until everything was dead.
So perhaps taking the Werewolf theme and twisting it to make them have a goal that is unexpected? Or perhaps the Dresden thing where they are magicians who can use magic to turn into Wolves/Werewolves?
Finally, perhaps they use Magick to escape a curse that was placed on all Werewolves to keep them bound from changing?