Sungrowler CADave has run both Tales from the Loop and StarTrek using a published adventure as a starting point. Apparently he has had good feedback that people have been really interested to follow along and see where the cast deviates from the tracks (which is almost everywhere) and how CADave handles that.
Your own world would be very interesting to see what you come up with. It allows for greater flexibiilty and tuning things to your world vision, which I can imagine to be fabulous.
Lastly, I think I heard of this pre-game game from somehwere. Decu something..., made by Adamantite Bolas Filly or someone? could give that a whirl and see what you and your favourite group of maniacs come up with 😉