Whew! Where to begin...
Firstly, I would register early and pay attention to when the event registrations open, because you can jump in and pre-reg on games you really want. However, don't overbook yourself. Most of the fun of the con is hanging out with people, make sure you leave room to do that. The con is relatively large, so if you want board games, LARPs, Adventure League, Pathfinder, Starfinder, Rifts OP, you'll find it.
Many of us hang out either on the second floor with the RPG department--there is always a healthy mix of good games and good GMs, Happy Jacks-affiliated people and others. Look out for the Happy Jacks streamed games if they continue to do that. On Sat and Sun @tomes runs Games on Demand and you could literally just sit there the entire time and get into any number of indy games with awesome players and designers without registering for a thing.
The podcast is Saturday night, so keep that open and we tend to drink afterward (and, I guess, during). Sometimes there's a late night shadowcon. Sunday morning is a designer meeting and then Kid's Games on Demand follows.
The hotel's room rates are reasonable, but try to get on the third floor so you don't have deal with the elevators. The food is expensive and not all that great, but you can't bring food into the con. So leave a healthy set of liquor, beer, and snacks in your room. If you're not a drinker, you'll save a fortune. If you are on the third floor you can join the rest of us as we meander up there in between sessions.
Try to come Thursday night if you can swing it, there's usually someone around to game with.
It's an amazing con with amazing people, I can count on one hand how many "meh" sessions I've played. Looking forward to seeing you!